HotHouse Therapeutics transforms plants into sustainable biofactories guided by AI, creating complex molecules beyond the reach of conventional labs. From next-generation vaccine adjuvants to breakthrough therapeutics, we discover novel compounds in days, not years.
Redefining drug discovery
The world urgently needs faster, smarter, and more sustainable ways to discover new therapies. HotHouse Therapeutics is answering that call with its BotanAI and BotanBio platforms that merge AI with plant bioengineering to open vast new chemical spaces.
We design and optimise molecules once thought impossible, moving from digital concept to high-purity compounds with unprecedented speed. Because our medicines grow in plants, they scale sustainably – carbon-positive by design and free from destructive extraction.
From pioneering vaccine adjuvants to entirely new classes of therapeutics, HotHouse Therapeutics is building not just a pipeline, but a platform to redefine what’s possible in drug discovery.
62%
Of current drugs are natural products
... or are natural product-inspired. The need for new chemistry has never been higher with an ever-increasing patient population urgently requiring new therapeutics.
>20 Mn
POTENTIAL BIOACTIVE NATURAL PRODUCTS
… are estimated to be made by the plants that currently inhabit the planet. The instruction manuals needed to make these natural products are hidden in the genomes of >400,000 plants.
2.4 Bn
POTENTIAL BIOSYNTHETIC GENES
… are waiting to be discovered and guided by our AI-platform, we can understand and harness these genes to synthesise new-to-nature therapeutics.Our Platform
BotanAI transforms plants into sustainable biofactories, unlocking vaccine adjuvants and new-to-nature therapeutics that chemistry alone can’t reach. By initiating and optimising compound design and delivery, BotanAI identifies the next generation of therapeutics.
BotanBio delivers the chemistry – from vaccine adjuvants to small molecule therapeutics, we deliver scalable, sustainable solutions for pharma, biotech, and global health. Combining BotanAI with our two novel plant expression systems, transient for development and stable for production, successfully translates complex AI-generated chemistry through to GMP.
Our Work
We engineer entire biosynthetic pathways, not just plants. By redesigning nature’s routes, we create greener, faster, smarter systems that yield molecules with precision – in days, not years. From refining known compounds to inventing new-to-nature chemistry, we turn complex biology into a powerful tool for rapid discovery.
Our Team
Our team blends decades of expertise in plant science, chemistry, and AI. United by a shared passion for unlocking nature’s chemistry to cure disease, these researchers, scientists, and industry experts are driving the future of plant-based therapeutics to cure disease.
News
HotHouse Therapeutics Attends WVC Europe 2025
This week, HotHouse Therapeutics joined the World Vaccine Congress Europe 2025 in Amsterdam, bringing our mission front and centre into the heart of the vaccine community. The event, held October 13-16 at RAI Amsterdam, covered the full vaccine value chain – from early R&D to large-scale manufacturing. Key Themes from WVC Europe 2025 Several discussions […]
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